i have a really heavy modded skyrim and i have to use SKSE to start my game but i use radeonPro for sweetFX but when i try to place skyrim on it with the preset i want to use i start up skyrim but no SFX is working on it but i can get SFX to work just fine on The Crew... Any help would be nice thanks.

Either try to launch it with SKSE or try to define SKSE as it's launcher (because i'm quite sure it still launches TESV.EXE when using SKSE). Worst case scenario if that doesn't work a manual install will work just fine.

screw it

I had similar problem