Cryptic Games' MMORPG based on the popular TV and film franchise. The game is free to play with a cash shop to buy specialized ships and services such as additional character slots.
You'll need to locate the Star Trek Online folder, it will vary depending if you've installed it via Arc, Steam or some other method. In that folder will be Star Trek Online.exe (this is actually the launcher).
The file you need to add a SweetFX profile for (or copy the SweetFX/Reshade DLLs to) is under .\Star Trek Online\Live. The actual game executable is GameClient.exe.
It uses DirectX 9. (There is an optional DirectX 9E renderer but it has a lot of bugs.)
If you alt-tab out of the game when the initial CRYPTIC title screen is up, the game will freeze for some reason.
Once the game proper is initialized, you can alt-tab as well as usual (it does wig the game out sometimes.)